Aim: This retrospective study aimed to evaluate the effectiveness of different management strategies for such patients and explore the clinical outcomes related to these treatments.
Methods: This was a retrospective study that included a total of 33 patients who presented with spontaneous intraabdominal hemorrhage at a tertiary care center. The patients’ demographics, clinical characteristics, laboratory findings, treatment modalities (conservative management, endovascular embolization), and outcomes were evaluated. Comparative statistical analyses were performed to assess the impact of treatment approaches on patient outcomes.
Results: The majority of patients were female (72.7%) and of Saudi nationality (72.7%). Warfarin (21.2%) and heparin (21.2%) were the most frequently prescribed anticoagulants. The study demonstrated a significant postoperative reduction in systolic blood pressure (p = 0.031), indicating the effectiveness of timely intervention. Furthermore, the conservative management approach showed significant preoperative and postoperative improvements in systolic blood pressure, hemoglobin levels, and platelet counts compared to endovascular embolization. Blood transfusion volumes were significantly lower in the conservative management group (p = 0.002). The presence of rebleeding postoperatively was borderline significant (p = 0.074), favoring patients undergoing endovascular embolization.
Conclusion: Effective management of spontaneous intraabdominal hemorrhage in anticoagulated and antiplatelet-treated patients is a multifaceted challenge.
License
This work is licensed under a Creative Commons Attribution 4.0 International license
References
- Demir M, Demir T, Yaylaci S, Genc A. Spontaneous abdominal hemorrhage due to warfarin treatment. CHRISMED J Health Res. 2016 Oct;3(4):298-302.
- Espil G, Larranaga N, Villarroel N, Oyarzun A, Matzke G, Kozima S. Spontaneous abdominal hemorrhage: imaging evaluation. Rev Argent Radiol. 2015;79(2):86-94.
- Gilard-Pioc S, Guerard P, Paraf F, François-Purssell I. Sudden death by spontaneous epiglottic hematoma secondary to high blood levels of warfarin. J Forensic Sci. 2017 Jul;62(4):1094-6.
- Chen DH, Soh KS, Wang YT, Shen TC. Warfarin-induced spontaneous intramural small bowel hematoma presenting as an acute abdomen: a case report. Medicine (Baltimore). 2022 Sep 9;101(35):e30122.
- Gómez-Outes A, Suárez-Gea ML, Lecumberri R, Terleira-Fernández AI, Vargas-Castrillón E. Direct-acting oral anticoagulants: pharmacology, indications, management, and future perspectives. Eur J Haematol. 2015 Nov;95(5):389-404.
- Makam RC, Hoaglin DC, McManus DD, Wang V, Gore JM, Spencer FA, et al. Efficacy and safety of direct oral anticoagulants approved for cardiovascular indications: systematic review and meta-analysis. PLoS One. 2018 May 24;13(5):e0197583.
- Hum J, Shatzel JJ, Jou JH, Deloughery TG. The efficacy and safety of direct oral anticoagulants vs traditional anticoagulants in cirrhosis. Eur J Haematol. 2017 Apr;98(4):393-7.
- Gunasekaran K, Rajasurya V, Devasahayam J, Singh Rahi M, Chandran A, Elango K, et al. A review of the incidence, diagnosis, and treatment of spontaneous hemorrhage in patients treated with direct oral anticoagulants. J Clin Med. 2020 Sep 15;9(9):2984.
- Öztürk EK, Kurtuluş E, et al. Anticoagulant related abdominal hematomas: clinical and CT findings. Akademik Gastroenteroloji Dergisi. 2018;17(2):50-61.
- Zhu Y, et al. Case report: spontaneous intramural hematoma of the colon secondary to low molecular weight heparin therapy. Front Pharmacol. 2021;12:598661.
- Hatjipetrou A, Anyfantakis D, Kastanakis M. Rectus sheath hematoma: a review of the literature. Int J Surg. 2015 Jan 1;13:267-71.
- Karapolat B, Tasdelen HA, Korkmaz HA. Conservative treatment of spontaneous rectus sheath hematomas: single center experience and literature review. Emerg Med Int. 2019 Feb 21;2019:6215193.
- Contrella BN, Park AW, Wilkins LR, Sheeran D, Hassinger TE, Angle JF. Spontaneous rectus sheath hematoma: factors predictive of conservative management failure. J Vasc Interv Radiol. 2020 Feb;31(2):323-30.
- Galyfos G, Karantzikos G, Palogos K, Sianou A, Filis K, Kavouras N. Spontaneous rectus sheath hematoma in the elderly: an unusual case and update on proper management. Case Rep Emerg Med. 2014;2014:503792.
- Khorsand N, Majeed A, Sarode R, Beyer-Westendorf J, Schulman S, Meijer K. Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH. J Thromb Haemost. 2016 Jan;14(1):211-4.
- Selma AB, Genese T. Spontaneous rectus sheath hematoma: an uncommon cause of acute abdominal pain. Am J Case Rep. 2019;20:163-7.
- Touma L, Cohen S, Cassinotto C, Reinhold C, Barkun A, Tran VT, et al. Transcatheter arterial embolization of spontaneous soft tissue hematomas: a systematic review. Cardiovasc Intervent Radiol. 2019 Mar;42(3):335-43.

