Objective
To determine diagnostic ability of brain magnetic resonance imaging (MRI) in detection of idiopathic intracranial hypertension (IIH).
Method
This descriptive observational study was conducted in radiology department from Jan. 2018 to Jan. 2021, evaluating MR imaging data of all adult patients (n=107) with clinical presentations of headaches. Patients with space occupying lesions, obstructive hydrocephalus and cerebral venous sinus thrombosis were excluded. Presence of all three brain MRI findings of (i) an empty sella (with or without sellar enlargement), (ii) tortuosity of optic nerves (with or without perioptic CSF prominence) and (iii) non-dilated (or slit-like) ventricles was considered positive for IIH. Imaging was reviewed by two neuroradiologists and consensus reporting was made. Findings of IIH were confirmed by presence of high lumbar opening cerebrospinal fluid (CSF) pressure or symptomatic response towards specific medical treatment. Outcomes of brain MRIs were presented on a 2x2 contingency table.
Results
Sensitivity, and specificity of routine brain MRI findings in detection of IIH were calculated as 76.4% [95% confidence interval (CI), 64.62-85.91%], and 84.6% (95% CI, 69.47-94.14%) respectively.
Conclusion:
IIH is a known cause of headache. Detection of all three findings of empty sella, tortuosity of optic nerves and non-dilated ventricles on routine brain MRI can predict IIH with greater sensitivity and specificity.
License
This work is licensed under a Creative Commons Attribution 4.0 International license
References
- Wall M. Update on Idiopathic Intracranial Hypertension. Neurol Clin. 2017 Feb;35(1):45–57. https://doi.org/10.1016/j.ncl.2016.08.004 PMID:27886895
- Thurtell MJ. Idiopathic Intracranial Hypertension. Continuum (Minneap Minn). 2019 Oct;25(5):1289–309. https://doi.org/10.1212/CON.0000000000000770 PMID:31584538
- Markey KA, Mollan SP, Jensen RH, Sinclair AJ. Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol. 2016 Jan;15(1):78–91. https://doi.org/10.1016/S1474-4422(15)00298-7 PMID:26700907
- Al Abdulsalam HK, Ajlan AM. Idiopathic intracranial hypertension in males. Neurosciences (Riyadh). 2017 Jul;22(3):220–3. https://doi.org/10.17712/nsj.2017.3.20170005 PMID:28678218
- Mallery RM, Rehmani OF, Woo JH, Chen YJ, Reddi S, Salzman KL, et al. Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema. J Neuroophthalmol. 2019 Sep;39(3):299–307. https://doi.org/10.1097/WNO.0000000000000767 PMID:30829949
- Ahmad SR, Moss HE. Update on the Diagnosis and Treatment of Idiopathic Intracranial Hypertension. Semin Neurol. 2019 Dec;39(6):682–91. https://doi.org/10.1055/s-0039-1698744 PMID:31847039
- Sundholm A, Träisk F, Hellgren K, Lundvall M, Söderman M, Gustavsson B, Nilsson Remahl I. Idiopatisk intrakraniell hyper¬tension – riktlinjer saknas ännu - Förslag till nationellt handläggningsstöd för utredning, behandling och uppföljning [Idiopathic intracranial hypertension - Swedish consensus guidelines]. Lakartidningen. 2019 May 15;116:FI3R. Swedish. PMID: 31192408.
- Smith SV, Friedman DI. The Idiopathic Intracranial Hypertension Treatment Trial: A Review of the Outcomes [Erratum in: Headache. 2018 Nov;58] [10] [:1697. PMID: 28758206]. Headache. 2017 Sep;57(8):1303–10. https://doi.org/10.1111/head.13144 PMID:28758206
- Pal A, Sengupta P, Biswas D, Sen C, Mukherjee A, Pal S. Pattern of Idiopathic Intracranial Hypertension in Indian Population. Ann Indian Acad Neurol. 2019 Jan-Mar;22(1):47–51. https://doi.org/10.4103/aian.AIAN_116_18 PMID:30692759
- Tan YJ, Choo CH. Idiopathic Intracranial Hypertension - Characteristic MRI Features. Headache. 2020 Oct;60(9):2083–4. https://doi.org/10.1111/head.13931 PMID:32757392
- Batur Caglayan HZ, Ucar M, Hasanreisoglu M, Nazliel B, Tokgoz N. Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. J Neuroophthalmol. 2019 Sep;39(3):324–9. https://doi.org/10.1097/WNO.0000000000000792 PMID:31430269
- Alkherayf F, Abou Al-Shaar H, Awad M. Management of idiopathic intracranial hypertension with a programmable lumboperitoneal shunt: early experience. Clin Neurol Neurosurg. 2015 Sep;136:5–9. https://doi.org/10.1016/j.clineuro.2015.05.018 PMID:26056804
- Alkali NH, Daif A, Dorasanamma M, Almoallem MA. Prognosis of idiopathic intracranial hypertension in Saudi Arabia. Ann Afr Med. 2011 Oct-Dec;10(4):314–5. https://doi.org/10.4103/1596-3519.87051 PMID:22064260
- Kwee RM, Kwee TC. Systematic review and meta-analysis of MRI signs for diagnosis of idiopathic intracranial hypertension. Eur J Radiol. 2019 Jul;116:106–15. https://doi.org/10.1016/j.ejrad.2019.04.023 PMID:31153551
- Bouffard MA. Fulminant Idiopathic Intracranial Hypertension. Curr Neurol Neurosci Rep. 2020 Mar;20(4):8. https://doi.org/10.1007/s11910-020-1026-8 PMID:32219578
- Karsy M, Abou-Al-Shaar H, Bowers CA, Schmidt RH. Treatment of idiopathic intracranial hypertension via stereotactic placement of biventriculoperitoneal shunts. J Neurosurg. 2018 Feb;130(1):136–44. https://doi.org/10.3171/2017.8.JNS162927 PMID:29393752
- Farrokhi Y, Sharif Kashani S, Aghsaei Fard M, Pakdel F, Yadegari S. Optic canal size in idiopathic intracranial hypertension and asymmetric papilledema. Clin Neurol Neurosurg. 2019 Sep;184:105376. https://doi.org/10.1016/j.clineuro.2019.105376 PMID:31176474
- Giridharan N, Patel SK, Ojugbeli A, Nouri A, Shirani P, Grossman AW, et al. Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature. Neurosurg Focus. 2018 Jul;45(1):E10. https://doi.org/10.3171/2018.4.FOCUS18100 PMID:29961379
- Sarica A, Curcio M, Rapisarda L, Cerasa A, Quattrone A, Bono F. Periventricular white matter changes in idiopathic intracranial hypertension. Ann Clin Transl Neurol. 2019 Jan;6(2):233–42. https://doi.org/10.1002/acn3.685 PMID:30847356
- Razek AA, Batouty NM, Azab AG. Role of susceptibility-weighted imaging in patients with idiopathic intracranial hypertension. Jpn J Radiol. 2020 Aug;38(8):740–5. https://doi.org/10.1007/s11604-020-00959-9 PMID:32236855
- Hartmann AJ, Soares BP, Bruce BB, Saindane AM, Newman NJ, Biousse V, et al. Imaging Features of Idiopathic Intracranial Hypertension in Children. J Child Neurol. 2017 Jan;32(1):120–6. https://doi.org/10.1177/0883073816671855 PMID:28195748
- Gaier ED, Heidary G. Pediatric Idiopathic Intracranial Hypertension. Semin Neurol. 2019 Dec;39(6):704–10. https://doi.org/10.1055/s-0039-1698743 PMID:31847041
- Aylward SC, Way AL. Pediatric Intracranial Hypertension: a Current Literature Review. Curr Pain Headache Rep. 2018 Feb;22(2):14. https://doi.org/10.1007/s11916-018-0665-9 PMID:29441432
- Kesler A, Kupferminc M. Idiopathic intracranial hypertension and pregnancy. Clin Obstet Gynecol. 2013 Jun;56(2):389–96. https://doi.org/10.1097/GRF.0b013e31828f2701 PMID:23563883

